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Diagnosis and Testing Methods for Recurrent Miscarriage: Six Common Causes and Approaches

Recurrent miscarriage refers to the occurrence of two or more consecutive miscarriages. For women who have experienced recurrent miscarriage, identifying the precise cause is key to developing an effective treatment plan. This article introduces six common causes of recurrent miscarriage, along with the diagnostic methods that can help in identifying these causes and managing the condition.

复发性流产检查,Recurrent Miscarriage Diagnosis

Table of Contents


1. Anatomical Factors and Diagnosis

Anatomical abnormalities of the uterus are one of the primary causes of recurrent miscarriage. These include uterine septum, fibroids, adhesions, and congenital malformations, all of which can interfere with embryo implantation and development.
Diagnosis Methods:

  • Ultrasound: Used to check the thickness of the uterine lining, the structure of the uterine cavity, and the presence of abnormalities such as fibroids.
  • Hysteroscopy: Provides a direct view of the uterine cavity and is used to diagnose uterine adhesions or other abnormalities.
  • Hysterosalpingography (HSG): Used to assess the shape of the uterine cavity and the patency of the fallopian tubes, helping to identify uterine malformations or adhesions.

2. Endocrine Factors and Diagnosis

Endocrine imbalances are a common cause of recurrent miscarriage. Conditions such as luteal phase defects, thyroid disorders (e.g., hyperthyroidism or hypothyroidism), and polycystic ovary syndrome (PCOS) can disrupt pregnancy.
Diagnosis Methods:

  • Blood Tests: To check thyroid function, luteal phase hormone levels, and other endocrine factors.
  • Hormone Level Monitoring: To assess key pregnancy-related hormones, such as progesterone, ensuring they are within normal levels for maintaining pregnancy.

3. Immune Factors and Diagnosis

Immune system abnormalities, especially the presence of anti-embryo antibodies, can damage the immune barrier between the embryo and the mother, leading to recurrent miscarriages.
Diagnosis Methods:

  • Anti-embryo Antibody Testing: Blood tests to detect antibodies that may interfere with the embryo’s development and the immune system’s support of pregnancy.

4. Genetic Factors and Diagnosis

Chromosomal abnormalities in the embryo are a common cause of early miscarriages. Approximately 2-5% of couples with recurrent miscarriages have chromosomal abnormalities.
Diagnosis Methods:

  • Chromosomal Analysis: Cytogenetic testing on both partners to check for structural chromosomal abnormalities that may be inherited, which can affect pregnancy outcomes.

5. Infectious Factors and Diagnosis

Infections caused by pathogens like Toxoplasmosis, cytomegalovirus (CMV), and rubella virus can affect the embryo via the placenta, leading to miscarriage.
Diagnosis Methods:

  • Blood Tests: Screening for infections before or during pregnancy to identify potential pathogens that may impact fetal development.

6. Lifestyle and Environmental Factors and Diagnosis

Unhealthy lifestyle choices and exposure to harmful environmental factors can increase the risk of recurrent miscarriage. Smoking, excessive alcohol consumption, and exposure to toxic chemicals such as heavy metals or pesticides can negatively affect pregnancy. Additionally, high stress levels and lack of sleep can disrupt endocrine balance.
Diagnosis Methods:

  • Health and Lifestyle Evaluation: Comprehensive assessments of the patient’s lifestyle, including smoking, alcohol consumption, and exposure to environmental toxins.

In conclusion, identifying the specific cause of recurrent miscarriage through comprehensive diagnostic testing is crucial for developing an individualized treatment plan. Understanding the underlying factors helps guide therapy and provides women with the best chance for a successful, healthy pregnancy.